Antibodies, Proteins, Kits and Reagents for Life Science

281 433 ₸ Product size

100 µg 281 433 ₸

Order now and get it on Thursday February 25, 2021

Key features and details

Product name

Anti-DLL3 antibody
See all DLL3 primary antibodies
Description

Rabbit polyclonal to DLL3
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Human

See all applications and species data
Immunogen

Synthetic peptide corresponding to Human DLL3 aa 550 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin.
(Peptide available as ab88189)
Positive control
- This antibody gave a positive signal in Human Liver Tissue Lysate.

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

Batches of this product that have a concentration
Concentration information loading...
Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab63707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Human

Application	Abreviews	Notes
WB		Use a concentration of 1 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).

Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).

Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Involvement in disease

Spondylocostal dysostosis 1
Sequence similarities

Contains 1 DSL domain.
Contains 6 EGF-like domains.
Domain

The DSL domain is required for binding to the Notch receptor.
Post-translational
modifications

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
Cellular localization

Membrane.
Target information above from: UniProt accession Q9NYJ7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
Database links
- Entrez Gene: 10683 Human
- Omim: 602768 Human
- SwissProt: Q9NYJ7 Human
- Unigene: 127792 Human
Alternative names
- Delta Drosophila like 3 antibody
- Delta like 3 Drosophila antibody
- Delta like 3 homolog Drosophila antibody
- Delta like 3 protein antibody
- Delta like protein 3 precursor antibody
- Delta-like protein 3 antibody
- Delta3 antibody
- Dll3 antibody
- DLL3_HUMAN antibody
- Drosophila Delta homolog 3 antibody
- SCDO1 antibody
- SCOD1 antibody
- Spondylocostal dysostosis autosomal recessive antibody
see all

Publishing research using ab63707? Please let us know so that we can cite the reference in this datasheet.

ab63707 has been referenced in 2 publications.

Zhang J et al. Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes. Oncol Lett 13:4533-4539 (2017). PubMed: 28599454
Wang J et al. EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway. Tumour Biol 39:1010428317706203 (2017). PubMed: 28705113