Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free (ab82888)
Key features and details
- Mouse monoclonal [GE2] to Dectin-1 - Low endotoxin, Azide free
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free
See all Dectin-1 primary antibodies -
Description
Mouse monoclonal [GE2] to Dectin-1 - Low endotoxin, Azide free -
Host species
Mouse -
Specificity
Human beta Glucagon Receptor has two major (ßGR-A and ßGR-B) and several minor isoforms. ßGR-A and ßGR-B differ by the presence and absence, respectively, of a stalk region. ab82888 (clone GE2) recognizes both isoform A and B. -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse
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Immunogen
Tissue, cells or virus corresponding to Human Dectin-1.
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Positive control
- Human peripheral blood monocytes
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: PBS -
Carrier free
Yes -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
Endotoxin level:Clonality
MonoclonalClone number
GE2Myeloma
Sp2Isotype
IgG1Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Target
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Function
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. -
Tissue specificity
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. -
Involvement in disease
Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
Sequence similarities
Contains 1 C-type lectin domain. -
Post-translational
modificationsPhosphorylated on tyrosine residues in response to glucan binding. -
Cellular localization
Cytoplasm and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 64581 Human
- Entrez Gene: 56644 Mouse
- Omim: 606264 Human
- SwissProt: Q9BXN2 Human
- SwissProt: Q6QLQ4 Mouse
- Unigene: 143929 Human
- Unigene: 239516 Mouse
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Alternative names
- Beta GR antibody
- Beta-glucan receptor antibody
- BGR antibody
see all
Datasheets and documents
References (5)
ab82888 has been referenced in 5 publications.
- Camilli G et al. Impaired phagocytosis directs human monocyte activation in response to fungal derived ß-glucan particles. Eur J Immunol 48:757-770 (2018). PubMed: 29313961
- Xiao Y et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med 22:906-14 (2016). PubMed: 27428899
- Bao Z et al. Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type II alveolar epithelial cells. BMC Microbiol 15:161 (2015). PubMed: 26268695
- Kyrmizi I et al. Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling. J Immunol 191:1287-99 (2013). PubMed: 23817424
- Han X et al. ß-1,3-Glucan-Induced Host Phospholipase D Activation Is Involved in Aspergillus fumigatus Internalization into Type II Human Pneumocyte A549 Cells. PLoS One 6:e21468 (2011). Flow Cyt, Inhibition Assay ; Human . PubMed: 21760893
