Anti-Cleaved Caspase-6 antibody (ab2326)
Key features and details
- Rabbit polyclonal to Cleaved Caspase-6
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Cleaved Caspase-6 antibody -
Description
Rabbit polyclonal to Cleaved Caspase-6 -
Host species
Rabbit -
Specificity
This antibody recognizes the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize any other caspase.
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Species reactivity
Reacts with: Rat, Human -
Immunogen
Synthetic peptide corresponding to Human Cleaved Caspase-6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.
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General notes
The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol, 0.5% BSA -
Concentration information loading... -
Purity
Immunogen affinity purified -
Primary antibody notes
The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas