Anti-CFTR antibody
See all CFTR primary antibodies

Rabbit polyclonal to CFTR

Rabbit

Detects cystic fibrosis transmembrane conductance factor (CFTR) from cells overexpressing the human protein.

Reacts with: Human
Predicted to work with: Rat, Sheep, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Monkey, Non human primates, Cynomolgus monkey, Rhesus monkey, Gorilla, Elephant

Synthetic peptide corresponding to Human CFTR aa 103-117.
Sequence:

GRIIASYDPDNKEER

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA

Immunogen affinity purified

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

Polyclonal

IgG

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