Anti-BTNL2 antibody (ab215053)
Key features and details
- Sheep polyclonal to BTNL2
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-BTNL2 antibody
See all BTNL2 primary antibodies -
Description
Sheep polyclonal to BTNL2 -
Host species
Sheep -
Specificity
The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS). -
Tested Applications & Species
See all applications and species dataApplication Species WB Mouse
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Immunogen
Recombinant fragment corresponding to Mouse BTNL2 aa 1 to the C-terminus. Mouse myeloma cell line NS0-derived
Database link: O70355 -
Positive control
- Lysates of mouse small intestine tissue
Properties
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Form
Lyophilized:Reconstitute the antibody with 100 uL sterile PBS and the final concentration is 500 ug/mL. Reconstituted antibody can also be aliquoted and stored frozen atStorage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.Storage buffer
Constituent: PBS
Concentration information loading...Purity
Immunogen affinity purifiedClonality
PolyclonalIsotype
IgGResearch areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab215053 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
GuaranteedTested applications are guaranteed to work and covered by our Abpromise guarantee.
PredictedPredicted to work for this combination of applications and species but not guaranteed.
IncompatibleDoes not work for this combination of applications and species.
Application Species WB MouseAll applications RatApplication Abreviews Notes WB 1/1000 - 1/2000.Notes WB
1/1000 - 1/2000.Target
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Function
Negative regulator of T cell proliferation. -
Tissue specificity
Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus. -
Involvement in disease
Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. -
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 3 Ig-like V-type (immunoglobulin-like) domains. -
Cellular localization
Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound. - Information by UniProt
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Database links
- Entrez Gene: 547431 Mouse
- Entrez Gene: 309620 Rat
- SwissProt: O70355 Mouse
- SwissProt: Q6MG97 Rat
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Alternative names
- BTL-II antibody
- Btnl2 antibody
- BTNL2_HUMAN antibody
see all
Images
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Western blot - Anti-BTNL2 antibody (ab215053)Anti-BTNL2 antibody (ab215053) at 1/1000 dilution + lysates from mouse small intestine tissue
Datasheets and documents
References (0)
ab215053 has not yet been referenced specifically in any publications.
Images
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Western blot - Anti-BTNL2 antibody (ab215053)Anti-BTNL2 antibody (ab215053) at 1/1000 dilution + lysates from mouse small intestine tissue
