Anti-AANAT antibody
See all AANAT primary antibodies

Rabbit polyclonal to AANAT

Rabbit

Reacts with: Rat
Predicted to work with: Mouse, Chicken, Hamster, Human, Chimpanzee, Rhesus monkey

Synthetic peptide corresponding to Mouse AANAT aa 1-100 (N terminal).
(Peptide available as ab5003)

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Total anti-N-terminal AA-NAT-specific IgG was affinity purified on resin-coupled non-phosphopeptide. Phospho-specific amino-terminal IgG was subsequently isolated on resin-coupled phosphopeptide.

Pineal gland serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light/dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr 29 and Ser 206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation.

Polyclonal

IgG

• Neuroscience
• Neurotransmitter
• Biogenic Amines
• Serotonin / 5HT

• Neuroscience
• Neurology process
• Circadian Rhythm
• Hormones

• Cancer
• Cancer Metabolism
• Metabolic signaling pathway
• Hormone biosynthesis

• Metabolism
• Pathways and Processes
• Endocrine metabolism
• Hormone biosynthesis

• Metabolism
• Types of disease
• Cancer