Ansamitocin P-3, microtubule depolymerizing agent (ab144546)
Key features and details
- Potent microtubule depolymerizing agent
- CAS Number: 66547-09-9
- Purity: > 95%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ansamitocin P-3, microtubule depolymerizing agent -
Description
Potent microtubule depolymerizing agent -
Biological description
Potent microtubule depolymerizing agent. Binds to tubulin at the vinblastine (ab145649) site. Induces p53-mediated apoptosis. Shows cytotoxic effects to tumor cell lines. Maytansine analog. Shows antitumor effects in vivo. Orally active. -
Purity
> 95% -
CAS Number
66547-09-9 -
Chemical structure
Properties
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Chemical name
3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate -
Molecular weight
635.20 -
Molecular formula
C32H43ClN2O9 -
PubChem identifier
5282049 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O -
Source
Synthetic
