Alvespimycin (17-DMAG) hydrochloride (ab273531)
Key features and details
- Potent Hsp90 inhibitor
- CAS Number: 467214-21-7
- Purity: > 99%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Alvespimycin (17-DMAG) hydrochloride -
Description
Potent Hsp90 inhibitor -
Biological description
A potent Hsp90 inhibitor (IC50 = 62 nM), can bind to the ATP-binding motif and inhibit the protein chaperoning activity.
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Purity
> 99% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
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CAS Number
467214-21-7 -
Chemical structure
Properties
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Chemical name
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin, hydrochloride
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Molecular weight
653.21 -
Molecular formula
C32H48N4O8.HCl -
PubChem identifier
9852573 -
Storage instructions
Shipped at 4°C. Store at -20°C. Please see notes section. -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC.Cl -
Source
Synthetic
Images
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Chemical Structure - Alvespimycin (17-DMAG) hydrochloride (ab273531)
Chemical structure of Alvespimycin (17-DMAG) hydrochloride, 467214-21-7
