Aloisine, CDK and GSK-3 inhibitor (ab143751)
Key features and details
- Cell-permeable, selective, potent, ATP-competitive inhibitor of CDKs and GSK-3.
- CAS Number: 496864-15-4
- DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Aloisine, CDK and GSK-3 inhibitor -
Description
Cell-permeable, selective, potent, ATP-competitive inhibitor of CDKs and GSK-3. -
Alternative names
- 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
- Aloisine RP106
- RP-106
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Biological description
Cell-permeable, selective, potent, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3 (IC50 values are 700nM, 1.5 µM, and 920 nM, respectively).
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CAS Number
496864-15-4 -
Chemical structure
Properties
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Chemical name
7-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine -
Molecular weight
281.35 -
Molecular formula
C17H19N3O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
