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AICAR (Acadesine/AICA riboside) (mM/ml), AMP-activated protein kinase activator (ab146713)

Key features and details

  • Cell-permeable activator of AMP-activated protein kinase. 1 ml water soluble pack.
  • CAS Number: 2627-69-2
  • Purity: > 98%
  • Soluble in 1 ml water to give specified mM/ml concentration
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    AICAR (Acadesine/AICA riboside) (mM/ml), AMP-activated protein kinase activator

  • Description

    Cell-permeable activator of AMP-activated protein kinase. 1 ml water soluble pack.

  • Alternative names

    • Acadesine
    • AICA riboside

  • Biological description

    Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity

    > 98%

  • CAS Number

    2627-69-2

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide

  • Molecular weight

    258.23

  • Molecular formula

    C9H14N4O5

  • PubChem identifier

    17513

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    NC(=O)c2ncn([C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O)c2N

  • Source

    Synthetic

  • Research areas

Images

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