AG-494, EGF receptor tyrosine kinase (ab141562)
Key features and details
- Potent, selective EGF receptor tyrosine kinase
- CAS Number: 133550-35-3
- Purity: > 99%
- Soluble in DMSO to 75 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AG-494, EGF receptor tyrosine kinase -
Description
Potent, selective EGF receptor tyrosine kinase -
Biological description
Potent, selective EGF receptor tyrosine kinase inhibitor (IC50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC50 values are 42, 6 and 100 μM respectively). Blocks CDK2 activation leading to cell cycle arrest at late G1 and during S phase. -
Purity
> 99% -
CAS Number
133550-35-3 -
Chemical structure
Properties
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Chemical name
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide -
Molecular weight
280.30 -
Molecular formula
C16H12N2O3 -
PubChem identifier
5328771 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in ethanol to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N -
Source
Synthetic
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Research areas