AG-126, Tyrosine kinase inhibitor (ab141572)
Key features and details
- Tyrosine kinase inhibitor
- CAS Number: 118409-62-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AG-126, Tyrosine kinase inhibitor -
Description
Tyrosine kinase inhibitor -
Biological description
Tyrosine kinase inhibitor. Inhibits glucocorticoid induced COX-2 activity (IC50 = 15 μM). Blocks lipopolysaccharide (LPS) induced TNFα synthesis and tyrosine phosphorylation of ERK2. Cell-permeable. Shows anti-inflammtory activity. Active in vivo. -
Purity
> 98% -
CAS Number
118409-62-4 -
Chemical structure
Properties
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Chemical name
2-[(3-Hydroxy-4-nitrophenyl)methylidene]propanedinitrile -
Molecular weight
215.20 -
Molecular formula
C10H5N3O3 -
PubChem identifier
2046 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-] -
Source
Synthetic
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Research areas
