AF12198, human type I interleukin receptor antagonist (ab141983)
Key features and details
- Antagonist for human type I interleukin receptor
- CAS Number: 185413-30-3
- Soluble in 3:1 water/acetonitrile to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AF12198, human type I interleukin receptor antagonist -
Description
Antagonist for human type I interleukin receptor -
Biological description
Potent and selective antagonist peptide for human type I interleukin-1 receptor (IL1R1) (IC50 values are 8 nM, > 6.7 µM and > 200 µM for hIL1R1,hIL1R2 and hIL1R1, respectively). Blocks IL-1-induced expression of ICAM-1 and reduces IL-1β-induced IL-6 and IL-8 production. Also exhibits anti-inflammatory activity. Active in vivo.
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CAS Number
185413-30-3 -
Chemical structure
Properties
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Molecular weight
1895.14 -
Molecular formula
C96H123N19O22 -
Sequence
FEWTPGWYQXYALPL (Modifications: N-terminal acetyl; C-terminal amide; X-10 = Aze) -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 3:1 water/acetonitrile to 1 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3c2cccc3)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N5CCC5C(=O)N[C@@H](Cc6ccc(cc6)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N7CCC[C@H]7C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](Cc8c[nH]c9c8cccc9)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)C)O -
Source
Synthetic