Adefovir Dipivoxil (bis-POM PMEA), nucleotide analog reverse transcriptase inhibitor (ab143063)
Key features and details
- Potent, selective, nucleotide analog reverse transcriptase inhibitor
- CAS Number: 142340-99-6
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Adefovir Dipivoxil (bis-POM PMEA), nucleotide analog reverse transcriptase inhibitor -
Description
Potent, selective, nucleotide analog reverse transcriptase inhibitor -
Alternative names
- bis-POM PMEA
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Biological description
Potent, selective, nucleotide analog reverse transcriptase inhibitor. Inhibits viral DNA synthesis (IC50 = 0.2-2.5 μM, HBV transfected human hepatoma cell lines). Shows antiviral effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
142340-99-6 -
Chemical structure
Properties
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Chemical name
[2-(6-Aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate -
Molecular weight
501.47 -
Molecular formula
C20H32N5O8P -
PubChem identifier
60871 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C -
Source
Synthetic
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Research areas
