• Product name

  Acetyl Coenzyme A Carboxylase peptide
  See all Acetyl Coenzyme A Carboxylase proteins and peptides

• Animal free

  No

• Nature

  Synthetic

• Alternative names

  • ACAC
  • ACACA
  • ACACA_HUMAN

  • ACACB
  • ACC
  • ACC alpha
  • ACC beta
  • ACC-alpha
  • ACC1
  • ACC2
  • ACCA
  • ACCB
  • Acetyl CoA carboxylase 1
  • Acetyl CoA carboxylase 2
  • Acetyl CoA carboxylase alpha
  • Acetyl CoA carboxylase beta
  • Acetyl Coenzyme A carboxylase alpha
  • Acetyl Coenzyme A carboxylase beta
  • Biotin carboxylase
  • COA1
  • COA2
  • HACC275
  • OTTHUMP00000164069
  • OTTHUMP00000164070
  • OTTHUMP00000164076
  • OTTHUMP00000240532

  see all

• Function

  Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

• Tissue specificity

  Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

• Pathway

  Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

• Involvement in disease

  Acetyl-CoA carboxylase 1 deficiency

• Sequence similarities

  Contains 1 ATP-grasp domain.
  Contains 1 biotin carboxylation domain.
  Contains 1 biotinyl-binding domain.
  Contains 1 carboxyltransferase domain.

• Post-translational
  modifications

  Phosphorylation on Ser-1263 is required for interaction with BRCA1.

• Cellular localization

  Cytoplasm.

• Target information above from: UniProt accession Q13085 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt