• Product name

  AANAT peptide
  See all AANAT proteins and peptides

• Animal free

  No

• Nature

  Synthetic

• Alternative names

  • AA-NAT
  • Aanat
  • Aralkylamine N-acetyltransferase

  • Arylalkylamine N acetyltransferase
  • Serotonin acetylase
  • Serotonin N-acetyltransferase
  • SNAT
  • SNAT_HUMAN

  see all

• Function

  Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

• Tissue specificity

  Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.

• Pathway

  Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.

• Involvement in disease

  Delayed sleep phase syndrome

• Sequence similarities

  Belongs to the acetyltransferase family. AANAT subfamily.
  Contains 1 N-acetyltransferase domain.

• Post-translational
  modifications

  cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.

• Cellular localization

  Cytoplasm.

• Target information above from: UniProt accession Q16613 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt