2-APB, Ca2+ release modulator (ab120124)
Key features and details
- Ca2+ release modulator
- CAS Number: 524-95-8
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
2-APB, Ca2+ release modulator -
Description
Ca2+ release modulator -
Biological description
Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.
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Purity
> 98% -
CAS Number
524-95-8 -
Chemical structure
Images
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Functional Studies - 2-APB, Ca2+ release modulator (ab120124) Kubota et al PLoS One. 2014; 9(9): e106316. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Induction of mGluR1-mediated inward current requires activation of TRPC1 but not TRPC3 in MLIs.
Time courses of the effects of SKF96365 (black circles, 30 µM, n = 4) and 2-APB (gray circles, 100 µM, n = 5) on the DHPG-induced inward current. A black bar indicates the time of drug application.
(From Figure 2 B of Kubota et al).