Z-LEHD-FMK, caspase-9 inhibitor (ab142026)
Key features and details
- Irreversible caspase-9 inhibitor
- CAS Number: 210345-04-3
- Purity: > 98%
Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Z-LEHD-FMK, caspase-9 inhibitor -
Description
Irreversible caspase-9 inhibitor -
Biological description
Irreversible caspase-9 inhibitor. Selective anti-apoptotic reagent, does not inhibit apoptosis in all biological systems. Neuroprotective. Cell-permeable. Active in vivo. -
Purity
> 98% -
CAS Number
210345-04-3 -
Chemical structure
Properties
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Molecular weight
690.70 -
Molecular formula
C32H43FN6O10 -
Sequence
LEHD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
44135217 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Supplied in DMSO (10 mM)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
See SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2 -
Source
Synthetic
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Research areas
Images
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Cellular activation - Z-LEHD-FMK, caspase-9 inhibitor (ab142026) Image from Beate Ronning S, et al. Plos One, 12(8), e0182928. Fig 6C and D,; doi: 10.1371/journal.pone.0182928
Differentiated muscle cells were pre-incubated with 20 µM Z-LEHD-FMK (irreversible caspas-9 inhibitor) for 30 min before exposure to anoxic conditions. C) Light microscopy pictures demonstrates morphological changes during anoxia treatment. Arrows indicate rounded up, dead cells. D) Live/dead analysis demonstrate increased number of dead cells during 6 h anoxia, but this is unaffected by the irreversible caspase-9 inhibitor.
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Functional Studies - Z-LEHD-FMK, caspase-9 inhibitor (ab142026)Functional assays: Caspase 9 Inhibitor Drug Detection Kit (ab102497)
Titration of the caspase 9 inhibitor Z-LEHD-FMK (ab142026) (duplicates; +/- SD).