Wogonin, COX-2 inhibitor (ab142471)
Key features and details
- Cell permeable COX-2 inhibitor
- CAS Number: 632-85-9
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Scutellaria Baicalensis Georgi
Overview
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Product name
Wogonin, COX-2 inhibitor -
Description
Cell permeable COX-2 inhibitor -
Biological description
Cell permeable COX-2 inhibitor (IC50 = 46 µM). Also inhibits CDK7 and CDK9 activity (IC50 values are 12.3 and 0.19 µM for CDK7 and CDK9 respectively). Anti-inflammatory reagent and apoptosis inducer. Active in vivo. -
Purity
> 98% -
CAS Number
632-85-9 -
Chemical structure
Properties
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Chemical name
5,7-Dihydroxy-8-methoxy-2-phenylchromen-4-one -
Molecular weight
284.26 -
Molecular formula
C16H12O5 -
PubChem identifier
5281703 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O -
Source
Scutellaria Baicalensis Georgi
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Research areas
Images
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Functional Studies - Wogonin, COX-2 inhibitor (ab142471)ab32087 staining MCL1 in HCT116 cells treated with wogonin (ab142471), by ICC/IF. Decrease of MCL1 expression correlates with increased concentration of wogonin, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab142471 (wogonin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32087 (1/100) dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.