VH298, VHL inhibitor (ab230370)
Key features and details
- Potent, cell permeable VHL inhibitor
- Purity: > 98%
100 mM in DMSO
100mM in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VH298, VHL inhibitor -
Description
Potent, cell permeable VHL inhibitor -
Biological description
VH298 is a cell permeable compound that binds tightly to VHL (KD = 80- 90 nM in in vitro binding assays) leading to cellular accumulation of HIF1-α. VH298 selectively stabilizes hydroxylated HIF1-α and induces HIF-dependent transcription.
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Purity
> 98% -
Chemical structure
Properties
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Chemical name
(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
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Molecular weight
523.65 -
Molecular formula
C27H33N5O4S -
PubChem identifier
122199236 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
100 mM in DMSO
100mM in ethanol
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SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O -
Source
Synthetic
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Research areas
