VEGFR2 Kinase Inhibitor I, receptor tyrosine kinase (RTK) inhibitor (ab145888)
Key features and details
- Highly selective, cell-permeable indolin-2-one class receptor tyrosine kinase (RTK) inhibitor for vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1).
- CAS Number: 15966-93-5
- Purity: > 95%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VEGFR2 Kinase Inhibitor I, receptor tyrosine kinase (RTK) inhibitor -
Description
Highly selective, cell-permeable indolin-2-one class receptor tyrosine kinase (RTK) inhibitor for vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). -
Alternative names
- 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, ethyl ester
- IN1018
- SU 5408
- VEGF Receptor 2 Kinase Inhibitor I
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Biological description
Highly selective, cell-permeable inhibitor of VEGFR2 kinase. Little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor.
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Purity
> 95% -
CAS Number
15966-93-5 -
Chemical structure
Properties
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Chemical name
(Z)-3-[[2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl]methylidenyl]indolin-2-one -
Molecular weight
310.40 -
Molecular formula
C18H18N2O3 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
