UCPH-102, EAAT1 inhibitor (ab146404)
Key features and details
- Selective EAAT1 inhibitor
- CAS Number: 1229591-56-3
- Purity: > 98%
- Soluble in DMSO to 25 mM. It is recommended that all preparations are centrifuged before use.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
UCPH-102, EAAT1 inhibitor -
Description
Selective EAAT1 inhibitor -
Biological description
Selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor (IC50 = 0.42 μM). Active in vivo. Blood-brain barrier permeable analog of UCPH-101 (ab120309).
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Purity
> 98% -
CAS Number
1229591-56-3 -
Chemical structure
Properties
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Chemical name
2-Amino-5,6,7,8-tetrahydro-4-methyl-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile -
Molecular weight
330.39 -
Molecular formula
C21H18N2O2 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM. It is recommended that all preparations are centrifuged before use. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C1CC(CC=2OC(N)=C(C#N)C(C)C1=2)c4cccc3ccccc34 -
Source
Synthetic
Images
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Functional Studies - UCPH-102, EAAT1 inhibitor (ab146404)Plot to compare the bioavailability of UCPH-102 in plasma versus brain.
