TW-37 (ab273490)
Key features and details
- Small molecule BCL-2 inhibitor
- CAS Number: 877877-35-5
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TW-37 -
Description
Small molecule BCL-2 inhibitor -
Biological description
Small-molecule inhibitor of BCL-2 (Ki = 0.29 μM). Inhibits multiple BCL-2 family members including BCL-XL (Ki = 1.11 μM) and MCL-1 (Ki = 0.26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2. Significant anti-proliferative and pro-apoptotic activity in lymphoma cells.
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Purity
> 98% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
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CAS Number
877877-35-5 -
Chemical structure
Properties
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Chemical name
N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
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Molecular weight
573.70 -
Molecular formula
C33H35NO6S -
PubChem identifier
11455910 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C -
Source
Synthetic
Images
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Chemical Structure - TW-37 (ab273490)
Chemical structure of TW-37, 877877-35-5
