TTFA, Mitochondrial Complex II inhibitor (ab223880)
Key features and details
- Mitochondrial Complex II inhibitor
- CAS Number: 326-91-0
- Purity: > 98%
Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TTFA, Mitochondrial Complex II inhibitor -
Description
Mitochondrial Complex II inhibitor -
Alternative names
- 2-Thenoyltrifluoroacetone
- Thenoyltrifluoroacetone
- TTB
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Biological description
Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 µM).
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Purity
> 98% -
CAS Number
326-91-0 -
Chemical structure
Properties
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Chemical name
2-Thenoyltrifluoroacetone
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Molecular weight
222.18 -
Molecular formula
C8H5F3O2S -
PubChem identifier
5601 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F -
Source
Synthetic
