TPCA 1, IkappaB kinase inhibitor (ab145522)
Key features and details
- Potent, selective IκB kinase inhibitor
- CAS Number: 507475-17-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TPCA 1, IkappaB kinase inhibitor -
Description
Potent, selective IκB kinase inhibitor -
Biological description
Potent, selective IκB kinase inhibitor (IC50 = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo.
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Purity
> 98% -
CAS Number
507475-17-4 -
Chemical structure
Properties
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Chemical name
2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide -
Molecular weight
279.29 -
Molecular formula
C12H10FN3O2S -
PubChem identifier
9903786 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F -
Source
Synthetic
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Research areas