Thiocolchicoside, GABAA antagonist (ab144375)
Key features and details
- Potent, competitive GABAA antagonist
- CAS Number: 602-41-5
- Purity: > 95%
- Soluble in water and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Thiocolchicoside, GABAA antagonist -
Description
Potent, competitive GABAA antagonist -
Biological description
Potent, competitive GABAA antagonist (IC50 = 145 nM). Suppresses cerebral vasospasm after subarachnoid hemorrhage. Suppresses RANKL-induced osteoclastogenesis. Shows muscle relaxant and anti-inflammatory effects in vivo. Orally active. -
Purity
> 95% -
CAS Number
602-41-5 -
Chemical structure
Properties
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Chemical name
N-[1,2-Dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide -
Molecular weight
563.62 -
Molecular formula
C27H33NO10S -
PubChem identifier
72067 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in water and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O -
Source
Synthetic
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Research areas