Tetrodotoxin, Na+ channel blocker (ab120054)
Key features and details
- Na+ channel blocker
- CAS Number: 4368-28-9
- Purity: > 98%
- Soluble in pH 4.8 citrate buffer to 100 mM
- Form / State: Solid
- Source: Fugu
Overview
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Product name
Tetrodotoxin, Na+ channel blocker -
Description
Na+ channel blocker -
Alternative names
- TTX
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Biological description
Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
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Purity
> 98% -
General notes
To purchase this product, additional information may be required for security reasons. Please contact customer services for further details.
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CAS Number
4368-28-9 -
Chemical structure
Properties
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Chemical name
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol -
Molecular weight
319.27 -
Molecular formula
C11H17N3O8 -
PubChem identifier
6324668 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in pH 4.8 citrate buffer to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O[C@H]3C14NC(=N)N[C@H](O)[C@@H]4C2O[C@]3(O)O[C@H](C1O)C2(O)CO -
Source
Fugu
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Research areas
Images
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Functional Studies - Tetrodotoxin, Na+ channel blocker (ab120054) Image from Gómez-Gonzalo M et al., PLoS Biol. 2010;8(4):e1000352. Fig 4(E).; doi: 10.1371/journal.pbio.1000352. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/TTX blocked the ictal discharge in both field A and B neurons, but not the direct response of field A neurons to a double NMDA pulse (black arrowheads).
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Functional Studies - Tetrodotoxin, Na+ channel blocker (ab120054) Image from Riebe I et al., BMC Neuroscience. 2012;13:14. Fig 1.; doi: 10.1186/1471-2202-13-14. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/2.0Multiple connections between CA3 and CA1 pyramidal cells and GABAergic cells and CA1 pyramidal cells in young adult rats. (A1) A typical recording at -80 mV from a pyramidal cell, upper trace shows AMPA sEPSCs under control conditions and lower trace shows mEPSCs after wash-in of TTX. (A2) TTX reduces the AMPA EPSC amplitude by 5.9 ± 0.8 pA (P = 0.004, n = 8, two-tailed paired t-test). (A3) TTX reduces AMPA EPSC frequency by 1.5 ± 0.4 Hz (P -
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