Teijin compound 1 hydrochloride, CCR2 antagonist (ab120823)
Key features and details
- Potent, selective CCR2 antagonist
- CAS Number: 1313730-14-1
- Purity: > 99%
- Soluble in water to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Teijin compound 1 hydrochloride, CCR2 antagonist -
Description
Potent, selective CCR2 antagonist -
Biological description
Potent, selective CCR2 antagonist (Ki = 180 nM). Inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).
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Purity
> 99% -
CAS Number
1313730-14-1 -
Chemical structure
Properties
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Chemical name
N-[2-[[(3R)-1-[(4-Chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride -
Molecular weight
476.32 -
Molecular formula
C21H21ClF3N3O2.HCl -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]3CCN(Cc2ccc(Cl)cc2)C3 -
Source
Synthetic
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Research areas
