TAK 165, ErbB2 inhibitor (ab141473)
Key features and details
- Potent, highly selective, irreversible ErbB2 inhibitor
- CAS Number: 366017-09-6
- Purity: > 98%
- Soluble in ethanol to 5 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TAK 165, ErbB2 inhibitor -
Description
Potent, highly selective, irreversible ErbB2 inhibitor -
Biological description
Potent, highly selective, irreversible ErbB2 inhibitor (IC50 = 6 nM). Shows potent antiproliferative effects (IC50 = 5 nM, ErbB2 overexpressing cancer cell lines). Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
366017-09-6 -
Chemical structure
Properties
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Chemical name
4-[[4-[4-(Triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole -
Molecular weight
468.47 -
Molecular formula
C25H23F3N4O2 -
PubChem identifier
6444692 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 75 mM -
Handling
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SMILES
C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F -
Source
Synthetic
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Research areas
