T2AA, Proliferating cell nuclear antigen (PCNA) inhibitor (ab146970)
Key features and details
- Proliferating cell nuclear antigen (PCNA) inhibitor
- CAS Number: 1380782-27-3
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
T2AA, Proliferating cell nuclear antigen (PCNA) inhibitor -
Description
Proliferating cell nuclear antigen (PCNA) inhibitor -
Alternative names
- T2 amino alcohol
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Biological description
Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 = ~1 µM). Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Causes DNA replication stress by stalling DNA replication forks. Suppresses cancer cell growth. T3 derivative that exhibits almost no thyroid hormone activity.
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Purity
> 98% -
CAS Number
1380782-27-3 -
Chemical structure
Properties
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Chemical name
(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol -
Molecular weight
511.10 -
Molecular formula
C15H15I2NO3 -
PubChem identifier
71185540 -
Storage instructions
Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC[C@@H](N)Cc2cc(I)c(Oc1ccc(O)cc1)c(I)c2 -
Source
Synthetic
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Research areas