SU-5402, VEGFR and FGFR inhibitor (ab141368)
Key features and details
- Potent, selective VEGFR and FGFR inhibitor
- CAS Number: 215543-92-3
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SU-5402, VEGFR and FGFR inhibitor -
Description
Potent, selective VEGFR and FGFR inhibitor -
Biological description
Potent, selective VEGFR and FGFR inhibitor (IC50 values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo.
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Purity
> 97% -
CAS Number
215543-92-3 -
Chemical structure
Properties
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Chemical name
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid -
Molecular weight
296.33 -
Molecular formula
C17H16N2O3 -
PubChem identifier
5289418 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O -
Source
Synthetic
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Research areas
