SU-5402 (DMSO solution), VEGFR and FGFR inhibitor (ab146602)
Key features and details
- Potent, selective VEGFR and FGFR inhibitor
- CAS Number: 215543-92-3
- Purity: > 98%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SU-5402 (DMSO solution), VEGFR and FGFR inhibitor -
Description
Potent, selective VEGFR and FGFR inhibitor -
Biological description
Potent, selective VEGFR and FGFR inhibitor (IC50 values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo.
Also available as a solid (ab141368). -
Purity
> 98% -
CAS Number
215543-92-3 -
Chemical structure
Properties
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Chemical name
3-[4-Methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid -
Molecular weight
296.33 -
Molecular formula
C17H16N2O3 -
PubChem identifier
5289418 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O -
Source
Synthetic