SGI1776 (ab273532)
Key features and details
- Novel ATP competitive inhibitor of Pim1
- CAS Number: 1025065-69-3
- Purity: > 99%
≥40.5 mg/mL in DMSO, ≥101 mg/mL in EtOH,insoluble in H2O
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SGI1776 -
Description
Novel ATP competitive inhibitor of Pim1 -
Biological description
Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.
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Purity
> 99% -
CAS Number
1025065-69-3 -
Chemical structure
Properties
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Chemical name
N-[(1-Methyl-4-piperidinyl)methyl]-3-[3- (trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
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Molecular weight
405.42 -
Molecular formula
C20H22F3N5O -
PubChem identifier
24795070 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
≥40.5 mg/mL in DMSO, ≥101 mg/mL in EtOH,insoluble in H2O
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2 -
Source
Synthetic
Images
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Chemical Structure - SGI1776 (ab273532)
Chemical structure of SGI1776, 1025065-69-3