SB 939, HDAC inhibitor (ab144404)
Key features and details
- Potent HDAC inhibitor
- CAS Number: 929016-96-6
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 939, HDAC inhibitor -
Description
Potent HDAC inhibitor -
Biological description
Potent HDAC inhibitor (IC50 = 77 nM, HDAC1). Shows antiproliferative effects in cancer cell lines (IC50 values are 480, 560, 480, and 340 nM for A2780, COLO 205 and HCT-116 and PC-3 lines respectively). Shows antitumor and potent antimalarial effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
929016-96-6 -
Chemical structure
Properties
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Chemical name
(E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide -
Molecular weight
358.48 -
Molecular formula
C20H30N4O2 -
PubChem identifier
49855250 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO -
Source
Synthetic
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Research areas
