SB 415286, GSK3 inhibitor (ab120962)
Key features and details
- Potent, selective GSK3 inhibitor
- CAS Number: 264218-23-7
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 415286, GSK3 inhibitor -
Description
Potent, selective GSK3 inhibitor -
Biological description
Potent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.
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Purity
> 99% -
CAS Number
264218-23-7 -
Chemical structure
Properties
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Chemical name
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione -
Molecular weight
359.73 -
Molecular formula
C16H10ClN3O5 -
PubChem identifier
4210951 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2NC(=O)C(=C2Cc1cc(Cl)c(O)cc1)c3ccccc3[N+]([O-])=O -
Source
Synthetic
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Research areas
