S14-95, JAK/STAT pathway inhibitor (ab144515)
Key features and details
- JAK/STAT pathway inhibitor
- CAS Number: 419532-92-6
- Purity: > 95%
Soluble in Methanol.
- Form / State: Lyophilized
- Source: Isolated from Penicillium sp.
Overview
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Product name
S14-95, JAK/STAT pathway inhibitor -
Description
JAK/STAT pathway inhibitor -
Biological description
JAK/STAT pathway inhibitor. Inhibits IFN-γ mediated expression of the reporter gene (IC50 values are 5.4 - 10.8 μM). Inhibits COX-2 and NOS II expression (IC50 = 10.8 μM). Inhibits iNOS-dependent NO production.
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Purity
> 95% -
CAS Number
419532-92-6 -
Chemical structure
Properties
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Chemical name
(3S,4aR,6aR,12aR,12bS)-3-(Acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-9-phenyl-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one
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Molecular weight
450.57 -
Molecular formula
C28H34O5 -
PubChem identifier
10983241 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in Methanol.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2CC4=C(O3)C=C(OC4=O)C5=CC=CC=C5)C)C -
Source
Isolated from Penicillium sp.
