Ro 106-9920, NF-kappaB inhibitor (ab144655)
Key features and details
- NF-κB inhibitor. Anti-inflammatory agent.
- CAS Number: 62645-28-7
- Purity: > 95%
- Soluble in ethanol to 10 mM and in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ro 106-9920, NF-kappaB inhibitor -
Description
NF-κB inhibitor. Anti-inflammatory agent. -
Biological description
NF-κB inhibitor. Anti-inflammatory agent. Selectively inhibits LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Inhibits TNF-α, IL-1β and IL-6 production. Shows anti-inflammatory effects in vivo. Orally active.
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Purity
> 95% -
CAS Number
62645-28-7 -
Chemical structure
Properties
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Chemical name
6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine -
Molecular weight
245.26 -
Molecular formula
C10H7N5OS -
PubChem identifier
3906779 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=S(c1nn2nnnc2cc1)c3ccccc3 -
Source
Synthetic
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Research areas
