RITA, p53 activator (ab219379)
Key features and details
- p53 activator
- CAS Number: 213261-59-7
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
RITA, p53 activator -
Description
p53 activator -
Alternative names
- 2,5-bis(5-hydroxymethyl-2-thienyl) Furan
- NSC 652287
- p53 Activator III
- Reactivation of p53 and induction of tumor cell apoptosis
-
Biological description
p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
-
Purity
> 98% -
CAS Number
213261-59-7 -
Chemical structure
Properties
-
Chemical name
5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol -
Molecular weight
292.37 -
Molecular formula
C14H12O3S2 -
PubChem identifier
374536 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO -
Source
Synthetic
-
Research areas
