Recombinant rat Prolactin Receptor/PRL-R protein (ab170083)
Key features and details
- Expression system: Insect cells
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- AI987712
- CLONE SPM213
- CPRLP
see all -
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. -
Tissue specificity
Expressed in breast, placenta, kidney, liver and pancreas. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Contains 2 fibronectin type-III domains. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Cellular localization
Secreted and Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant rat Prolactin Receptor/PRL-R protein (ab170083)SDS-PAGE analysis of ab170083.
Lane 1: 3 µg reduced
Lane 2: 3 µg Non-reduced
Lane 3: Molecular weight markers -
Functional Studies - Recombinant rat Prolactin Receptor/PRL-R protein (ab170083)Inhibition of prolactin-induced proliferation of Nb2-11 rat lymphoma cells by ab170083.
