Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Escherichia coli
Purity: > 95% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies, HPLC

Alternative names
- C-C motif chemokine 12
- Ccl12
- CCL12_MOUSE
- Macrophage/monocyte Chemotactic Protein
- MCP-1-related chemokine
- MCP-5
- Monocyte chemoattractant protein 5
- Monocyte chemotactic protein 5
- OTTMUSP00000000792
- Scya12
- Small inducible cytokine A12
- Small-inducible cytokine A12
see all
Function

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Tissue specificity

Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.
Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.
Cellular localization

Secreted.
Target information above from: UniProt accession Q62401 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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