Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human TRAIL protein (Active) (ab256115)

Key features and details

Expression system: Escherichia coli
Purity: > 90% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Alternative names
- Apo 2 ligand
- APO 2L
- Apo-2 ligand
- Apo-2L
- APO2L
- CD253
- CD253 antigen
- Chemokine tumor necrosis factor ligand superfamily member 10
- Protein TRAIL
- TL2
- TNF Related Apoptosis Inducing Ligand
- TNF related apoptosis inducing ligand TRAIL
- TNF-related apoptosis-inducing ligand
- TNF10_HUMAN
- TNFSF10
- TRAIL
- Tumor necrosis factor (ligand) family member 10
- Tumor Necrosis Factor (ligand) Superfamily Member 10
- Tumor necrosis factor apoptosis inducing ligand splice variant delta
- Tumor necrosis factor ligand superfamily member 10
see all
Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Tissue specificity

Widespread; most predominant in spleen, lung and prostate.
Sequence similarities

Belongs to the tumor necrosis factor family.
Cellular localization

Membrane.
Target information above from: UniProt accession P50591 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant human TRAIL protein (Active) (ab256115)

SDS-PAGE analysis of ab256115 (1μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions. ab256115 is predicted to have a MW of 19.5 kDa.

4-20% Tris-Glycine gel. Coomassie Blue staining

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