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Recombinant Human ROR1 protein (Tagged) (ab269987)

Key features and details

  • Expression system: HEK 293 cells
  • Tags: Avi tag C-Terminus, Fc tag C-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human ROR1 protein (Tagged)
    See all ROR1 proteins and peptides

  • Purity

    >90% by SDS-PAGE.

  • Expression system

    HEK 293 cells

  • Accession

    Q01973

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQ TAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDT TDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPY RGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFA IPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMI LMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRG TVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPW CFTLDENFKSDLCDIPACDSKDSKEKNKME

    • Predicted molecular weight

      71 kDa including tags

    • Amino acids

      24 to 403

    • Tags

      Avi tag C-Terminus , Fc tag C-Terminus

    • Additional sequence information

      C-terminal Avi-TagTM fused to the Fc portion of Human IgG1. NM_005012

Preparation and Storage

  • Alternative names

    • dJ537F10.1
    • Inactive tyrosine protein kinase transmembrane receptor ROR1
    • MGC99659
    • Neurotrophic tyrosine kinase
    • Neurotrophic tyrosine kinase receptor related 1
    • Neurotrophic tyrosine kinase, receptor related 1
    • NTRKR1
    • OTTHUMP00000010573
    • OTTHUMP00000010574
    • OTTMUSP00000008344
    • Receptor tyrosine kinase like orphan receptor 1
    • receptor-related 1
    • RGD1559469
    • ROR 1
    • ROR1
    • ROR1_HUMAN
    • RP11 24J23.1
    • Tyrosine kinase like orphan receptor 1
    • Tyrosine protein kinase transmembrane receptor ROR1
    • Tyrosine-protein kinase transmembrane receptor ROR1
    see all

  • Function

    Tyrosine-protein kinase receptor whose role is not yet clear.

  • Tissue specificity

    Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    Contains 1 FZ (frizzled) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 kringle domain.
    Contains 1 protein kinase domain.

  • Developmental stage

    Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human ROR1 protein (Tagged) (ab269987)
    SDS-PAGE - Recombinant Human ROR1 protein (Tagged) (ab269987)

    SDS-Page analysis of 4 µg ab269987 (Lane 1).

  • Size Exclusion Chromatography - Recombinant Human ROR1 protein (Tagged) (ab269987)
    Size Exclusion Chromatography - Recombinant Human ROR1 protein (Tagged) (ab269987)

    Aggregation analysis of ab269987.

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