Recombinant human Prorenin protein (Active) (ab93266)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE
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Product name
Recombinant human Prorenin protein (Active)
See all Prorenin proteins and peptides -
Biological activity
Fully activatable to renin by catalytic amounts of trypsin.
ab93266 is > 95% active.
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Purity
> 95 % SDS-PAGE.
ab93266 is purified by affinity chromatography. -
Expression system
HEK 293 cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Predicted molecular weight
44 kDa
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Preparation and Storage
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Alternative names
- Angiotensin forming enzyme
- Angiotensinogenase
- FLJ10761
see all -
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. -
Involvement in disease
Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. -
Sequence similarities
Belongs to the peptidase A1 family. -
Cellular localization
Secreted. Membrane. Associated to membranes via binding to ATP6AP2. - Information by UniProt
Images
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SDS-PAGE - Recombinant human Prorenin protein (ab93266)
3 ug of ab93266 on 10% SDS-PAGE.
Lane 1: Non-reduced
Lane 2: Reduced
Lane 3: Prestained Standard
