Recombinant human NKp30 protein (Fc Chimera Active) (ab184896)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: SDS-PAGE, ELISA
Preparation and Storage
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Alternative names
- 1C7
- Activating natural killer receptor p30
- Activating NK A1 receptor
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Function
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. -
Tissue specificity
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. -
Sequence similarities
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 1 Ig-like (immunoglobulin-like) domain. -
Cellular localization
Cell membrane. - Information by UniProt
Images
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ELISA - Recombinant human NKp30 protein (Fc Chimera) (ab184896)
Immobilized Human B7-H6, His Tag at 10 μg/mL (100 μL/well) can bind ab184896 with a linear range of 2-78 ng/mL.
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SDS-PAGE - Recombinant human NKp30 protein (Fc Chimera) (ab184896)SDS-PAGE of reduced ab184896 stained overnight with Coomassie Blue. The protein migrates as 50-58 kDa due to glycosylation.