Recombinant human MERTK protein (Active) (ab271471)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: Flow Cyt, SDS-PAGE
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Product name
Recombinant human MERTK protein (Active)
See all MERTK proteins and peptides -
Biological activity
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
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Purity
>= 90 % SDS-PAGE. -
Expression system
Baculovirus infected Sf9 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
EDVVIDRNLL ILGKILGEGE FGSVMEGNLK QEDGTSLKVA VKTMKLDNSS QREIEEFLSE AACMKDFSHP NVIRLLGVCI EMSSQGIPKP MVILPFMKYG DLHTYLLYSR LETGPKHIPL QTLLKFMVDI ALGMEYLSNR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI AIESLADRVY TSKSDVWAFG VTMWEIATRG MTPYPGVQNH EMYDYLLHGH RLKQPEDCLD ELYEIMYSCW RTDPLDRPTF SVLRLQLEKL LESLPDVRNQ ADVIY -
Predicted molecular weight
60 kDa including tags -
Amino acids
578 to 872 -
Tags
GST tag N-Terminus -
Additional sequence information
Genbank: NM_006343
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Preparation and Storage
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Alternative names
- c MER
- c mer proto oncogene tyrosine kinase
- c-mer
see all -
Function
In case of filovirus infection, seems to function as a cell entry factor. -
Tissue specificity
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. -
Involvement in disease
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant Human MERTK protein (Tagged) (ab271471)
Specific activity of ab271471.
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
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SDS-PAGE - Recombinant Human MERTK protein (Tagged) (ab271471)SDS-PAGE analysis of ab271471.