Recombinant Human LEFTY2 protein (His tag) (ab215580)
Key features and details
- Expression system: Mammalian
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C.
pH: 7.40
Constituent: PBS -
ReconstitutionReconstitute with ddH2O to a concentration no less than 100 µg/mL.Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at
General Info
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Alternative names
- EBAF
- Endometrial bleeding associated factor
- Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily)
see all -
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. -
Tissue specificity
Mesenchymal cells of the endometrial stroma. -
Involvement in disease
Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. -
Sequence similarities
Belongs to the TGF-beta family. -
Developmental stage
Transiently expressed before and during menstrual bleeding. -
Post-translational
modificationsThe processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab215580 has not yet been referenced specifically in any publications.
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