Recombinant Human ICOS Ligand/ICOSL protein (Tagged) (Biotin) (ab271378)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Tags: His tag C-Terminus, Avi tag C-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human ICOS Ligand/ICOSL protein (Tagged) (Biotin)
See all ICOS Ligand/ICOSL proteins and peptides -
Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAATWS -
Predicted molecular weight
31 kDa including tags -
Molecular weight information
Protein MW appears higher than predicted on SDS-PAGE due to glycosylation. -
Amino acids
19 to 258 -
Tags
His tag C-Terminus , Avi tag C-Terminus -
Additional sequence information
Genbank: NM_001283050
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Conjugation
Biotin
Preparation and Storage
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Alternative names
- B7 H2
- B7 homolog 2
- B7 homologue 2
see all -
Function
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. -
Tissue specificity
Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. -
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - (ab271378)
SDS-PAGE analysis of 6 μg of ab271378.
