Recombinant human Follistatin protein (Active) (ab256229)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- Activin binding protein
- Activin-binding protein
- Follistatin
see all -
Function
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). -
Tissue specificity
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. -
Sequence similarities
Contains 3 follistatin-like domains.
Contains 3 Kazal-like domains.
Contains 1 TB (TGF-beta binding) domain. -
Cellular localization
Secreted. - Information by UniProt
Images
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Functional Studies - Recombinant human Follistatin protein (Active) (ab256229)
Neutralization of human Activin A induced cytotoxicity of MPC-11 cells ≤200 ng/mL; ≥ 5.0 x 10E3 units/mg.
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SDS-PAGE - Recombinant human Follistatin protein (Active) (ab256229)4-20% SDS-PAGE - Recombinant human Follistatin protein (Active) (ab256229, 1µg per lane).
Lane 1: Non-reducing conditions.
Lane 2: Reducing conditions.
Coomassie blue staining.
