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Recombinant human Follistatin protein (Active) (ab256229)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Preparation and Storage

  • Alternative names

    • Activin binding protein
    • Activin-binding protein
    • Follistatin
    • FS
    • fst
    • FST_HUMAN
    • Human follistatin gene
    see all

  • Function

    Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

  • Tissue specificity

    Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

  • Sequence similarities

    Contains 3 follistatin-like domains.
    Contains 3 Kazal-like domains.
    Contains 1 TB (TGF-beta binding) domain.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • Functional Studies - Recombinant human Follistatin protein (Active) (ab256229)
    Functional Studies - Recombinant human Follistatin protein (Active) (ab256229)

    Neutralization of human Activin A induced cytotoxicity of MPC-11 cells ≤200 ng/mL; ≥ 5.0 x 10E3 units/mg.

  • SDS-PAGE - Recombinant human Follistatin protein (Active) (ab256229)
    SDS-PAGE - Recombinant human Follistatin protein (Active) (ab256229)

    4-20% SDS-PAGE - Recombinant human Follistatin protein (Active) (ab256229, 1µg per lane).

    Lane 1: Non-reducing conditions.
    Lane 2: Reducing conditions.
    Coomassie blue staining.

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