Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human Caspase-14 protein (ab173054)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: HPLC, SDS-PAGE

Description

  • Product name

    Recombinant Human Caspase-14 protein

  • Purity

    > 95 % SDS-PAGE.
    ab173054 is greater than 95% pure, as determined by SEC-HPLC and reducing SDS-PAGE. It is supplied as an 0.2 µM filtered solution.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    P31944

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFES TMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDG EMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVM VIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKG HILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQLEHHHHHH

    • Predicted molecular weight

      29 kDa including tags

    • Amino acids

      1 to 242

    • Tags

      His tag C-Terminus

    • Specifications

    Our Abpromise guarantee covers the use of ab173054 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      HPLC

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on Dry Ice. Store at -20°C long term. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituent: 100% PBS

    General Info

    • Alternative names

      • Apoptosis related cysteine protease
      • CASP 14
      • CASP-14
      • CASP14
      • Caspase 14 apoptosis related cysteine protease
      • Caspase 14 precursor
      • Caspase-14 subunit p10
      • Caspase14
      • CASPE_HUMAN
      • MGC119078
      • MGC119079
      • MICE
      • Mini ICE
      see all

    • Function

      Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.

    • Tissue specificity

      Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.

    • Sequence similarities

      Belongs to the peptidase C14A family.

    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab173054? Please let us know so that we can cite the reference in this datasheet.

ab173054 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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