Recombinant human Activin A Receptor Type IB/ALK-4 protein (Fc Chimera Active) (ab182676)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 92% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE, ELISA
Preparation and Storage
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Alternative names
- Activin A receptor type 1B
- Activin A receptor type II like kinase 4
- Activin A type 1B receptor
see all -
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2. -
Tissue specificity
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Post-translational
modificationsAutophosphorylated. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant human Activin A Receptor Type IB/ALK-4 protein (Fc Chimera) (ab182676)
Immobilized Human Activin A, Tag Free at 10µg/mL (100 µL/well) can bind ab182676 with a linear range of 0.313-5 μg/mL.
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SDS-PAGE - Recombinant human Activin A Receptor Type IB/ALK-4 protein (Fc Chimera) (ab182676)The purity of ab182676 was determined by DTT-reduced (+) and non-reduced (-) SDS-PAGE and staining overnight with Coomassie Blue. As a result of glycosylation, the protein migrates as 43-46 kDa under reducing condition, and 85-90 kDa under non-reducing condition.
